Volume 3, Issue 7, 2020, Page 377 - 388
Author(s) :
Nooshin Imani 1 , Mehrdad Modaresi *2
1 Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2 Department of Physiology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran


Abstract :
Medicinal plants have been considered from ancient times to reduce the symptoms of Parkinson\\\\\\\'s disease; however, the effective doses of these drugs are not known. The aim of this study was to compare the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model. Sixty mature mice in the weight range of 25 to 30 g were divided into seven groups: control, Parkinson’s, selegiline, and 50,100, and 200 mg/kg of hydro-alcoholic extract of rosemary. In order to induce Parkinson\\\\\\\'s disease, rotenone poison was injected intraperitoneal in 1, 2, and 3 mg/kg doses every other day for 19 days. Control group received only rotenone carrier (dimethyl sulfoxide and sunflower oil) in 48 ml/kg dose. Rearing and Bar behavioral models were used to evaluate the disease. Hydro-alcoholic extract of rosemary in 200 mg/kg dose increased the duration of animal\\\\\\\'s presence on 10 cm bar significantly and the number of animal attempts in 20 cm glass cylinder which indicate reduction of Parkinson’s symptoms. Also, this dose increased movement activity of mice significantly. According to results, rosemary’s extracts can affect Parkinson’s symptoms dose dependently.

Keywords :
Parkinson, rosemary, rotenone, selegiline, laboratory mice


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Receive Date
22 Aug 2020
Revise Date
24 Oct 2020
Accept Date
02 Nov 2020